Play as Pikachu and interact with many Pokémon! Players guide Pikachu through the adventure to save the PokéPark! You can meet many other Pokémon who appear in the game and talk to them. Characters in PokéPark Wii: Pikachu's Adventure speak with the same voices from the Pokémon animated TV series and movies! Much of the appeal of PokéPark Wii: Pikachu's Adventure is seeing the Pokémon interact with and speak to each other. There is a great variety of Pokémon for Pikachu to become friends with!

Unlike traditional Pokémon games, which generally trend toward RPG style gameplay facilitated by arena battles with multiplayer options, PokéPark Wii: Pikachu's Adventure is a single player action-adventure whose progress is mostly tied to mini-game play. Playing as the iconic Pokémon, Pikachu, the goal is to save PokéPark by finding shards of an object know as the "Sky Prism." These are hidden throughout the 14 themed zones that make up the gameworld, which Pikachu enters and searches with the aid of other Pokémon encountered. To get this aid Pikachu must make friends with these Pokémon. This is sometimes tied to combat, but is generally achieved by besting Pokémon in one of many mini-game style competitions, categorized as either attractions, skill games or cleaning duty. As is always the case in the Pokémon universe, all these Pokémon have different special skills and attributes. This is the point of befriending them, since once befriended players can utilize any Pokémon in mini-game play. Players can also upgrade certain skills by cashing in berries hidden throughout the game that serve as currency. Finally, players can utilize in-game photo functionality to capture moments from the game which can then be saved via Wii SD memory card functionality.